The Nanticoke Coal Power Plant is the largest coal-fired power plant in North America, delivering up to 3,640 MW of power into the southern Ontario power grid from its base in Nanticoke, Ontario, Canada. Nanticoke Generating Station is owned by Ontario Power Generation, a crown corporation of the Government of Ontario. It was scheduled for decommission in early 2009 as part of the Ontario commitment to eliminate coal power, but this has been repeatedly delayed. The plant is scheduled to phase out its use of coal by 2014, and switch to using biomass.

Environment Canada lists the Nanticoke station as the largest single source of greenhouse gas emissions and pollution anywhere in Canada.

Nanticoke Coal Power Plant is the largest coal-fired power plant in North America. The station's annual production is in the range of 20 to 24 billion kilowatt-hours (kWh), enough electricity to run nearly 2.5 million households. When demand for electricity is high, all eight units are put into service and it produces approximately 15% of Ontario's electricity needs by itself. Nanticoke's staff of about 600 includes power engineers, technicians, mechanical and electrical maintenance tradespeople, equipment operators, environmental technicians, managers and administrators.